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The increasing number of disease cases in humans worldwide creates the need for the development of novel strategies for prevention, control and treatment of Campylobacter infections. In frame with the One Health concept, the goal of this project is to lower the incidence of human infections by a reduction of the Campylobacter burden in meat production. To achieve this, we are proposing several coordinated lines of research: in the first line, we will establish and implement intervention strategies along the poultry production chain in order to limit pathogen colonisation and spread in affected animals. Based on these data, a risk intervention model that simulates the impact of the specific interventions will be generated and tested in frame with the reduction of the Campylobacter load in chicken meat. These data are completed by integrative research activities focusing on the role of the environment for Campylobacter epidemiology by investigating farm emissions and by the study of pathogen survival strategies outside the host. In the second line, we will apply various in vitro assays and in vivo animal models to develop novel therapeutic approaches to combat Campylobacter infection and/or limit post-infectious sequelae in humans. The combined expertise of veterinary/ human medicine as well as environmental sciences and epidemiology in this One Health approach will enable us to tackle the multifaceted socioeconomic problems associated with Campylobacter infections.