Fachbereich Veterinärmedizin



    Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells (2014)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Noe, Elena
    Tabeling, Christoph
    Doehn, Jan-Moritz
    Naujoks, Jan
    Opitz, Bastian
    Hippenstiel, Stefan
    Witzenrath, Martin
    Klopfleisch, Robert (WE 12)
    Annals of anatomy / Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft; 196(5) — S. 365–371
    ISSN: 0940-9602
    DOI: 10.1016/j.aanat.2014.04.001
    Pubmed: 24862691
    Institut für Tierpathologie

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    Abstract / Zusammenfassung

    Megaesophagus in mice has been associated with several genetic defects. In the present study we expand the range of genes associated with esophageal function and morphology by protein kinase C alpha (PKCα). PKCα-deficient mice showed a six times increased prevalence of megaesophagus at the age of 9-10 weeks compared to wild-type animals. In contrast, in a restricted number of 14-month-old animals of both genotypes a similar prevalence of megaesophagus was found. Megaesophagus was associated with an increased portion of the distal esophagus lined by smooth muscle cells. Achalasia-like degeneration or loss of neuronal cells, inflammation or fibrosis was not present in any of the animals. The results of the study therefore suggest that PKCα expression is associated with a delayed replacement of embryonic smooth muscle by skeletal muscle at the distal esophagus and consecutive megaesophagus in young mice, which, however, is not present at the same prevalence at an advanced age.