Publikationsdatenbank

Modulation of specific and allergy-related immune responses by helminths (2011)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Daniłowicz-Luebert, Emilia

O'Regan, Noëlle L

Steinfelder, Svenja

Hartmann, Susanne

Quelle

Journal of Biomedicine and Biotechnology

Bandzählung: 2011

Seiten: 1 – 18

ISSN: 1110-7243

Sprache

Englisch

Verweise

URL (Volltext): http://edocs.fu-berlin.de/docs/receive/FUDOCS_document_000000019820

DOI: 10.1155/2011/821578

Pubmed: 22219659

Kontakt

Institut für Immunologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51834
immunologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Helminths are master regulators of host immune responses utilising complex mechanisms to dampen host protective Th2-type responses and favour long-term persistence. Such evasion mechanisms ensure mutual survival of both the parasite and the host. In this paper, we present recent findings on the cells that are targeted by helminths and the molecules and mechanisms that are induced during infection. We discuss the impact of these factors on the host response as well as their effect in preventing the development of aberrant allergic inflammation. We also examine recent findings on helminth-derived molecules that can be used as tools to pinpoint the underlying mechanisms of immune regulation or to determine new anti-inflammatory therapeutics.