Fachbereich Veterinärmedizin



    Regulation of type 2 immunity to helminths by mast cells (2012)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Hepworth, Matthew R
    Maurer, Marcus
    Hartmann, Susanne
    Gut microbes; 3(5) — S. 476–481
    ISSN: 1949-0976
    Pubmed: 22892692
    Institut für Immunologie und Molekularbiologie

    Robert-von-Ostertag-Str. 7-13
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    14163 Berlin
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    Abstract / Zusammenfassung

    Recently, we demonstrated a novel role for gastrointestinal mast cells (MCs) in the early events that lead to the generation of Th2 immunity to helminth infection. Mice lacking MCs (Kit(W) /Kit(W-v) and Kit(W-Sh)) showed a significant inhibition of Th2 cell priming following infection with the parasitic helminth Heligmosomoides polygyrus bakeri (Hp). We showed that MCs degranulate during the early stages of infection when the helminth larvae invade the small intestinal tissue. Furthermore, MC degranulation was required for the enhanced expression and production of the tissue-derived cytokines IL-25, IL-33 and TSLP, which are required for the optimal orchestration and priming of type 2 immunity. In this addendum we aim to address several questions raised by our findings - in particular, the mechanisms through which MCs may recognize helminth exposure in the early stages of infection and by which they may enhance expression of critical tissue cytokines thus, enabling Th2 priming. Furthermore, we will discuss these findings in the context of recently described novel innate immune cells, such as type 2 hematopoietic progenitors and type 2 innate lymphoid cells.