Fachbereich Veterinärmedizin



    Serum osteocalcin in donkeys as evaluated with an equine-specific radioimmunoassay (2004)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Carstanjen, B
    Amory, H
    Youssao, I
    Remy, B
    Journal of animal physiology and animal nutrition; 88(1/2) — S. 1–6
    ISSN: 0931-2439
    Pubmed: 19774757
    Klinik für Pferde, allgemeine Chirurgie und Radiologie

    Oertzenweg 19 b
    14163 Berlin
    +49 30 838 62299

    Abstract / Zusammenfassung

    The purpose of this study was to validate an equine-specific osteocalcin (OC) radioimmunoassay (RIA) for use in donkeys and to establish age-related changes in serum OC concentrations in healthy donkeys. Serial dilutions of donkey serum showed parallelism with standard curves obtained with the equine-specific OC RIA. There was a tight linear regression between donkey serum OC values obtained with the equine specific OC RIA and a commercially available bovine-specific OC RIA. Serum OC levels of 27 healthy donkeys, analysed with the equine-specific OC RIA, showed a tight negative logarithmic regression with age. Least square means and standard error of serum OC values were 67 +/- 10 microg/l in 0.6-4-year-old donkeys (group 1), 32 +/- 9 microg/l in 5-9-year-old donkeys (group 2) and 15 +/- 11 microg/l in > 9-year-old donkeys (group 3). Serum OC values were significantly (p < 0.01) higher in group 1 than in groups 2 and 3. The equine-specific OC RIA may be a useful and practical tool to assess bone metabolism and skeletal diseases in donkeys.