Publikationsdatenbank

Concentration of D-dimers in healthy cats and sick cats with and without disseminated intravascular coagulation (DIC) (2009)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Tholen, Inger

Weingart, Christiane

Kohn, Barbara

Quelle

Journal of feline medicine and surgery : official journal of the European Society of Feline Medicine

Bandzählung: 11

Heftzählung: 10

Seiten: 842 – 846

ISSN: 1098-612x

Sprache

Englisch

Verweise

DOI: 10.1016/j.jfms.2009.04.008

Pubmed: 19539510

Kontakt

Klein- und Heimtierklinik

Oertzenweg 19 b
14163 Berlin
+49 30 838 62422
kleintierklinik@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The objective of this prospective study was to measure concentrations of D-dimers in 48 cats with various diseases and in 20 healthy cats to evaluate the sensitivity and specificity for D-dimers to diagnose disseminated intravascular coagulation (DIC). The cats were classified as having DIC if an underlying disease and at least three of the following criteria were present: thrombocytopenia, prolonged activated partial thromboplastin time, prothrombin time or thrombin time, schistocytes and/or a reduced antithrombin activity. D-dimer concentrations were measured using a semi-quantitative latex agglutination (LA) test (Accuclot D-Dimer, Sigma Diagnostics). The D-dimer test was positive for 8/12 cats with DIC and for 16/36 sick cats without DIC. D-dimers were negative for all healthy control cats. The comparison of the sick cats with DIC and those without DIC revealed a specificity and sensitivity of the D-dimer test of 56% and 67%; a comparison of the results for healthy cats and cats with DIC revealed a specificity and sensitivity of 100% and 67%, respectively. The D-dimer LA test is only of limited value for the diagnosis of DIC in cats.