Fachbereich Veterinärmedizin



    Myoglobin as a prognostic indicator for outcome in dogs with gastric dilatation-volvulus (2009)

    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Adamik, Katja N
    Burgener, Iwan A
    Kovacevic, Alan
    Schulze, Sebastian P
    Kohn, Barbara
    Journal of Veterinary Emergency and Critical Care; 19(3) — S. 247–253
    ISSN: 1476-4431
    DOI: 10.1111/j.1476-4431.2009.00421.x
    Pubmed: 19691509
    Klinik für kleine Haustiere

    Oertzenweg 19 b
    Haus 1
    14163 Berlin
    +49 30 838 62356

    Abstract / Zusammenfassung

    To determine whether myoglobin (Mb) is a useful prognostic indicator for outcome and to investigate any relationship between Mb and mortality in dogs with gastric dilatation-volvulus (GDV).

    Prospective study.

    Veterinary teaching hospital.

    Seventy-two dogs with GDV.

    Blood sampling.

    Mb levels were measured at the time of diagnosis (Mbt0), 24 hours (Mbt1), and 48 hours (Mbt2) after signs of GDV were recognized. Fifty-seven dogs survived (group I) and 15 dogs did not survive (group II). Mbt0 differed significantly between groups (P=0.04). Mbt0 in group I ranged from <30 to >700 ng/mL (n=57, median 74 ng/mL), and in group II from 34 to >700 ng/mL (n=15, median 238 ng/mL). Analysis of a receiver operating characteristic curve of Mbt0 suggested that the best single cutpoint would be 168 ng/mL (sensitivity 60.0%, specificity 84.2%). Fifty percent of dogs with Mbt0>168 ng/mL were euthanized, while 88.9% with Mbt0<168 ng/mL survived. Mbt1 and Mbt2 differed significantly between groups I and II. Mbt1 in group I ranged from 32 to >700 ng/mL (n=55, median 123 ng/mL), and Mbt1 in group II ranged from 131 to 643 ng/mL (n=7, median 343 ng/mL) (P=0.006). Mbt2 in group I ranged from 30 to 597 ng/mL (n=54, median 101 ng/mL), and in group II from 141 to >700 ng/mL (n=8, median 203 ng/mL) (P=0.02).

    In this study, Mbt0 is a moderately sensitive and specific prognostic indicator. Almost 90% of the dogs below the cutpoint survived to discharge, whereas 50% with Mbt0 above the cutpoint did not survive.