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The history of the fight against rabies (with special consideration to horses and other ungulates such as cows, sheeps, goats and pigs) is reviewed from the earliest period of written sources to present.The thesis is divided into sections, which represent the political, territorial and cultural events with consideration to medical and veterinarial knowledge of various historical epochs.Historical case studies of rabies of domesticated animals provide a basis of this thesis. The spread of rabies in Europe is discussed while acknowledging recognized theories of origin, treatment and immunization.Up to the Middle Ages all recorded data are sporadic, limited and in many cases incomplete. However reports about the common practice of prophylaxis and therapy give the most reliable information about the earliest treatment of rabies.This treatment was on the most part futile as the knowledge of rabies was limited and therefore the disease became a starting-point of many mystical stories.in the second half of the 19th century he pathogenic code was gradually deciphered. The development of a vaccine by Pasteur, who inoculated a human being for the first time in 1885, per-formed the first successful step to the control of the epidemic. Further research was carried out up to the beginning of the 20th century with more valid statistical recordings about the frequency of the disease.Many epidemics appeared in the first half of the 20th century due to World War 1 and 11. Finally national and international focus on this epidemic brought it under control.Comparison is shown between immunization of domesticated animals and wild animals (foxes) against rabies. This deadly disease, which has posed a permanent danger, is the subject of this scientific paper.