Oertzenweg 19 b
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Between 1993-2007, six horses with neurological signs - diagnosed "activated Bornavirus-infection"- were examined. The diagnosis was based on the detection of BDV-antibodies and/or BDV-antigen in blood samples(five cases) and of BDV-specific circulating immune complexes (CIC) in plasma (two cases) by an ELISA-based sandwich assay. The clinically suspected neurological disordes could be confirmed in three cases by histological findings. Case 1 showed equine degenerative myeloencephalopathy. Case 2 was found to have a massive lymphocytic infiltration mainly consisting of T-cells in the leptomeninx of the brain stem and cervical spinal cord. Case 3 exhibited a trigeminal ganglionitis and chronic degenerative neuropathy. For two further cases, the cause of neurological signs remained unclear. Another case showed a purulent necrotic colitis and peritonitis caused by an infection with Salmonella spp. In summary, all cases did not exhibit the typical non purulent meningoencephalitis which is regularly present in BD of hoses. In all six cases, no evidence of a BDV infection was found by various virological and immunohistological investigations. Therefore, the postmortem examinations did not confirm the antemortem diagnosis of "activated Bornavirus-infection".