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The goal of this study is to establish reference values for various blood biochemistry parameters in the guinea pig Cavia porcellus. Concentrations of the electrolytes sodium and calcium, the enzymes ALT, AST, GLDH and AP, and the metabolites urea, creatinine, glucose and protein were evaluated. The influences of age and gender were evaluated. 176 guinea pigs were physically examined of which 112 were included in the study. 13% of these were less than one year of age and 87% older than 12 months. 38% were female and 62% male. Blood was obtained by venepunctureof the lateral saphenous vene. The samples were examined by photometric analysis (AU 800, Olympus) at the Laborgemeinschaft Berliner Using statistical analysis, atypical results were discarded. Levels of sodium, calcium and protein were found to follow a normal distribution. Variance analysis was used to investigate the influences of age and gender. The differing variances of the parameters were evaluated by the Welch test. The 95% percentile was used as the reference range. Ranges for glucose and creatinine showed high significant gender differences -the values for females minimal lower than for males. GLDH is also significantly gender-dependent, showing higher values in females than males. AP is significantly age-dependent. Animals of an age less than 12 months old showed levels significantly higher than the group older than 12 months. Comparing these reference values with those of other animal species, it is obvious that the range of values obtained for glucose are strikingly widely-distributed with a extraordinarily low values. Ranges for other parameters are broadly comparable. Previously published blood chemistry reference ranges for guinea pigs differ significantly both from each other and from those presented here. Such values may not be applicable to guinea pigs presented in small animal practice.