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    Potential markers for detection of circulating canine mammary tumor cells in the peripheral blood (2011)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    da Costa, A
    Oliveira, J T
    Gärtner, F
    Kohn, B
    Gruber, A D
    Klopfleisch, R
    Quelle
    The veterinary journal; 190(1) — S. 165–168
    ISSN: 0372-5545
    Sprache
    Englisch
    Verweise
    DOI: 10.1016/j.tvjl.2010.09.027
    Pubmed: 21051248
    Kontakt
    Klinik für kleine Haustiere

    Oertzenweg 19 b
    Haus 1
    14163 Berlin
    +49 30 838 62356
    kleintierklinik@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Major discrepancies exist between histological predictions and actual metastatic potential of canine mammary tumors. Detection of circulating tumor cells (CTC) has a proven prognostic value for human breast cancer but similar markers for canine CTC are lacking. In the present study a panel of 16 human CTC markers was tested for their ability to specifically and sensitively detect canine carcinoma cells in peripheral blood. PCR assays for CK19, ERBB2, EGFR, CLDN7 and ELF3 were able to sensitively detect one carcinoma cell in up to 10(7) peripheral blood leukocytes. These CTC markers are thus candidate markers for identifying canine mammary CTC in the peripheral blood and may serve as prognostic factors for metastatic behavior in the future.