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    Leukoencephalomalacia and laminar neuronal necrosis following smoke inhalation in a dog (2011)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Weiss, A Th A
    Graf, C
    Gruber, A D
    Kohn, B
    Quelle
    Veterinary Pathology; 48(5) — S. 1016–1019
    ISSN: 0300-9858
    Sprache
    Englisch
    Verweise
    DOI: 10.1177/0300985810384412
    Pubmed: 20940447
    Kontakt
    Klinik für kleine Haustiere

    Oertzenweg 19 b
    Haus 1
    14163 Berlin
    +49 30 838 62356
    kleintierklinik@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Acute respiratory and neurologic disease after smoke inhalation are well documented, but human patients may also develop delayed-onset neurologic symptoms associated with leukoencephalomalacia after exposure to smoke or carbon monoxide. In this case, a dog developed progressive neurologic signs 6 days after rescue from an apartment fire. At necropsy 9 days after smoke inhalation, leukoencephalomalacia of the central cerebral white matter was accompanied by laminar necrosis of cerebrocortical neurons. This is the first report of delayed posthypoxic leukoencephalopathy in a nonhuman animal.