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    Seasonally activated spermatogenesis is correlated with increased testicular production of testosterone and epidermal growth factor in mink (Mustela vison) (2006)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Blottner, Steffen
    Schön, Jennifer
    Jewgenow, Katarina
    Quelle
    Theriogenology; 66(6/7) — S. 1593–1598
    ISSN: 0093-691x
    Sprache
    Englisch
    Verweise
    Pubmed: 16481033
    Kontakt
    Institut für Veterinär-Biochemie

    Oertzenweg 19 b
    14163 Berlin
    +49 30 838 62225
    biochemie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Seasonal changes in spermatogenesis were studied with respect to testicular production of both testosterone and epidermal growth factor (EGF) in mink. The testes were collected in November (n = 15; testis recrudescence), February (n = 15; before breeding season), March (n = 14; breeding season), and May (n = 11; testis involution) and the following parameters of testicular activity were quantified: testicular mass, number of testicular spermatozoa, percentages of haploid, diploid, and tetraploid (G2/M-phase) cells and content of testosterone and EGF. The growth factor was immunohistochemically localized in the parenchyma. Testis mass, spermatogenic activity, and the production of both testosterone and EGF were maximal in March, but were not significantly different from the levels in February. The correlation between testis weight and sperm per testis was r = 0.825 (P < 0.001). Testosterone and EGF levels were correlated to each other (r = 0.78; P < 0.001) and had significant positive correlations to testis mass, number of sperm and proportion of haploid cells; and negative correlations to percentages of mitotic cells. EGF was localized in interstitial cells and in the luminal region of seminiferous tubules, where it occurred during the last steps of spermiogenesis. We inferred that intensified seasonal spermatogenesis was stimulated by testosterone and by autocrine/paracrine effects of EGF.