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    Tumorigenic potential and the molecular mechanism of the carcinogenic effect exerted by 2-nitroanisole (2006)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Esmaeili, A
    Schlatterer, K
    Demirhan, I
    Schlatterer, B
    Nauck, M
    Chandra, P
    Chandra, A
    Quelle
    Anticancer research; 26(6B) — S. 4203–4212
    ISSN: 0250-7005
    Sprache
    Englisch
    Verweise
    Pubmed: 17201134
    Kontakt
    Institut für Veterinär-Biochemie

    Oertzenweg 19 b
    14163 Berlin
    +49 30 838 62225
    biochemie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    The host-mediated in vitro/in vivo assay system was used to evaluate the tumorigenic potential of the aromatic nitro compound 2-nitroanisole (2-NA). After intraperitoneal administration of the compound, resident macrophages were recovered by peritoneal lavage from treated and untreated mice and cultured in soft agar. 2-NA was shown to be carcinogenic, and the tumorigenic potential was evaluated. Additionally, by establishment of a transformed peritoneal macrophage cell line, the underlying molecular mechanism of 2-NA's carcinogenic effect was studied.