Publikationsdatenbank

Tumorigenic potential and the molecular mechanism of the carcinogenic effect exerted by 2-nitroanisole (2006)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Esmaeili, A

Schlatterer, K

Demirhan, I

Schlatterer, B

Nauck, M

Chandra, P

Chandra, A

Quelle

Anticancer research

Bandzählung: 26

Heftzählung: 6B

Seiten: 4203 – 4212

ISSN: 0250-7005

Sprache

Englisch

Verweise

Pubmed: 17201134

Kontakt

Institut für Veterinär-Biochemie

Oertzenweg 19 b
14163 Berlin
+49 30 838 62225
biochemie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The host-mediated in vitro/in vivo assay system was used to evaluate the tumorigenic potential of the aromatic nitro compound 2-nitroanisole (2-NA). After intraperitoneal administration of the compound, resident macrophages were recovered by peritoneal lavage from treated and untreated mice and cultured in soft agar. 2-NA was shown to be carcinogenic, and the tumorigenic potential was evaluated. Additionally, by establishment of a transformed peritoneal macrophage cell line, the underlying molecular mechanism of 2-NA's carcinogenic effect was studied.