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    Wirksamkeit einer vaginalen Progesteronspange zur Verringerung embryonaler Verluste in der Frühträchtigkeit bei Milchkühen (2012)

    Art
    Zeitschriftenartikel / wissenschaftlicher Beitrag
    Autoren
    Pilz, M.
    Fischer-Tenhagen, C.
    von Krueger, X.
    Heuwieser, W.
    Quelle
    Tierärztliche Praxis / Ausgabe G, Großtiere, Nutztiere; 40(1) — S. 7–13
    ISSN: 1434-1220
    Kontakt
    Tierklinik für Fortpflanzung

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    Abstract / Zusammenfassung

    The objective of this study was to test the efficacy of a progesterone
    releasing device (CIDR®, Pfizer, Germany) inserted on day (d) 20 post insemination
    (p. i.) to reduce embryonic losses between d 27 and 39 p. i.
    Furthermore, we hypothesized that CIDR® increases blood progesterone
    levels during the application period, but does not affect the maintenance
    of pregnancy after removal. Material and methods: The
    study was conducted on a commercial dairy farm, randomly allocating
    74 Holstein Friesian cows to one of two groups. These cows were nonpregnant
    after previous artificial insemination and treated with an Ovsynch
    protocol. Group 1 (n = 36) received a CIDR® on d 20 p. i. (CIDR®
    group) while group 2 (n = 38) remained untreated (control group).
    CIDR® was removed on d 39 p. i. Blood samples were drawn from all
    cows on d 20, 27, 39 and 55 p. i. for analysis of progesterone (P4) concentrations
    by immunoassay (ADVIA Centaur®, Siemens, Germany).
    Pregnancy diagnosis was conducted on d 27 p. i. with ultrasonography,
    and on d 39 and 55 p. i. by transrectal palpation. Results: The overall
    prevalence rate of early embryonic losses between d 27 and 39 p. i. was
    37.1% (CIDR® group 35.3%, control group 38.9%; p = 0.83). On
    d 39 p. i. 30.5% of all cows were pregnant and the percentage of pregnant
    cows did not differ between the study groups (p = 0.83). Progesterone
    levels on d 20 p. i. did not differ among cows which were pregnant
    on d 39 p. i. (p = 0.57). On d 27 p. i. progesterone levels in pregnant
    cows were higher in the CIDR® group (16.2 ± 9.9 ng/ml) compared
    to the control group (11.2 ± 3.4 ng/ml; p = 0.04). Progesterone concentrations
    were lower on d 39 p. i., but still differed between study groups
    (p = 0.05). After removal of CIDR®, blood progesterone levels did not
    differ between pregnant cows of both study groups on d 55 p. i.
    (p = 0.36). Conclusion: The application of a progesterone releasing device
    led to increased blood progesterone levels during the application
    period, but did not affect maintenance of pregnancy after its removal.
    Clinical relevance: Supplementation with progesterone at d 20 p. i.
    does not decrease early embryonic losses between d 27 and 39 p. i. or
    increase the number of cows pregnant on d 39 p. i.