Publikationsdatenbank

Hyaluronic acid concentrations in synovial fluid of dogs with different stages of osteoarthritis (2013)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Plickert, H D (WE 20)

Bondzio, Angelika (WE 3)

Einspanier, Ralf (WE 3)

Tichy, A

Brunnberg, Leo (WE 20)

Quelle

Research in Veterinary Science

Bandzählung: 94

Heftzählung: 3

Seiten: 728 – 734

ISSN: 0034-5288

Sprache

Englisch

Verweise

DOI: 10.1016/j.rvsc.2012.11.007

Pubmed: 23261156

Kontakt

Institut für Veterinär-Biochemie

Oertzenweg 19 b
14163 Berlin
+49 30 838 62225
biochemie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

To compare hyaluronic acid (HA) concentrations measured in synovial fluid (SF) of joints with different stages of canine secondary osteoarthritis (OA), clinical-orthopedic, radiographic, macroscopic intra-operative and SF findings of 49 joints were assessed. The sum of single findings was correlated to HA concentrations measured by a commercially available ELISA. Joints were categorized into three OA-groups: non-osteoarthritic, mildly osteoarthritic, and severely osteoarthritic. A significant negative correlation was found between severity of OA and HA concentrations (r=-0.696; P<0.001). Median values of HA concentrations decreased with increasing severity of the disease. Statistically significant differences in HA concentrations were observed between the OA-groups (P<0.001). Due to overlapping values between groups, it was concluded that synovial HA concentrations may only indicate a trend of osteoarthritic disease activity, but is not suitable for staging the disease.