Fachbereich Veterinärmedizin



    Mammatumore bei der Katze und ihre Metastasierung in den Axillarlymphknoten und in den Knochen sowie Untersuchungen zu eventuellen Frühformen von Mammatumoren bei der Katze (2004)

    Schirren, Katja
    Berlin, 2004 — 89 Seiten
    ISBN: 3-929171-58-9
    Institut für Tierpathologie

    Robert-von-Ostertag-Str. 15
    Gebäude 12
    14163 Berlin
    +49 30 838 62450

    Abstract / Zusammenfassung

    Summary The mammary chains of 30 cats submitted for autopsy to the Institut of Veterinary Pathology of the Freie Universität Berlin in the time 01.01.1999 - 31.03.1999 have been examined histologically for earlier diagnosis of a prestate of mammary carcinoma. 4 slides of 3 µm thickness of two ca. 2 cm long samples per mammacomplex have been made respectively. These samples were stained with Haematoxylin & Eosin and investigated histologically. In 464 samples there was no early diagnosis of a prestate, mainly atrophy and fibrosis predominated. In the second examination 12 cats with malignant mammary tumors submitted for autopsy to the Institut for Veterinary Pathology of the Freie Universtät Berlin in the time 01.01.1999- 31.08.2000 have been investigated for metastasis of the axillary lymphnodes and of the bones. Altogether 18 axillary lymphnodes and 767 bone samples have been examined histologically and immunohistologically. Immunohistochemistry is carried out with the modified BS-A- method and the anticytokeratin AE 1. All mammary tumors are of the adenocarcinoma variety, multiplicity occures in 8 cases and primary tumors are found mainly in the abdominal complexes of the mammary chain. 13% of the supposed axillary lymphnodes of the 12 cats have a macrometastasis: one lymphnode had a metastasis in spite of the primary tumour have been mostly in the caudal complex. This shows a new viewpoint perhaps for lymphdrainage. In 767 bone samples metastasis of an adenocarcinoma can be proved in 10 samples; that means 33% of the examined cats. The metastases are found mainly in the bone marrow; one metastasis just consisted of ca. 15 tumorous cells and was found in a Havers-channel in the substantia compacta. The metastases are lokalized in Tibia, Humerus, Tarsus and vertebra. No metastasis are found in the phalanges. Therefore bone metastasis definetly occurs more than supposed. However only in individual cases this bone metastasis will show clinical signs, because earlier metastasis like lungmetastasis will lead to earlier death. Single tumorcells or micrometastasis that occurs fequently in dogs haven't been found and that leads to a conclusion about the biological behaviour of mammary tumours. These results show the aggressiveness of this disease in cats and urgency of an early diagnosis to estimate further therapy.