Fachbereich Veterinärmedizin



    Intrauterine application of enzymes for the treatment of chronic endometritis in dairy cattle (2004)

    Drillich, M.
    Raab, D.
    Wittke, M.
    Heuwieser, W.
    XXIII World Buiatrics Congress
    Quebec/Kanada, 11. – 16.07.2004
    Le medecin veterinaire du Quebec 34, (1,2)
    — S. 140
    Tierklinik für Fortpflanzung

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    Abstract / Zusammenfassung

    Chronic endometritis in dairy cattle is associated with decreased reproductive
    performance and economic losses to the farmer. The treatment is based on the
    use of PGF2α and its analogues, or the intrauterine application of antibiotics or
    disinfectants. The efficacy of PGF2α and antibiotics is well documented.
    However, due to the risk of residues and resistances, the use of hormones and
    antibiotics in food producing animals is under critical public discussion. The use
    of proteolytic enzymes is established in the non-antibiotic treatment of mastitis
    in dairy cattle. The objective of this study was to evaluate the use of enzymes in
    the treatment of chronic endometritis. In a field trial, cows with vaginal
    discharge diagnosed 21-27 days post partum (dpp) were randomly assigned to
    two treatment groups. Endometritis was classified into three categories,
    depending on the type of vaginal discharge: clear mucus with flakes of pus
    (E 1), mucopurulent discharge (E 2), and purulent discharge (E 3). Cows in
    Group A (n=192) received an intrauterine infusion containing the enzymes
    trypsin, chymotrypsin, and papain. Cows in Group B (n=228) were treated with
    0.5 mg of the PGF2α-analogue cloprostenol. All cows were re-examined 35 to
    41 dpp. In Group A, cows were re-treated with enzymes if signs of endometritis
    were found, while in Group B all cows received a second injection of
    cloprostenol regardless of clinical findings. After a voluntary wait period of 72
    days cows were bred following an observed estrus. Clinical cure rate after the
    first treatment was 59.4 % and 68.1 % in groups A and B, respectively (p>0.05).
    Days to first service, conception rates, percentages of cows pregnant and days
    open were not significantly different between the groups. In both groups,
    clinical cure rate and reproductive performance were better for cows with E1 or
    E 2 than with E3, respectively. From the results of this study, it may be
    concluded that the local use of proteolytic enzymes is a promising approach for
    the treatment of chronic endometritis in dairy cows. However, PGF2α is still the
    treatment of choice for chronic endometritis.