Fachbereich Veterinärmedizin



    Treatments of chronic endometritis in dairy cows with prostaglandin F2alpha or proteolytic enzymes compard to a placebo group (2005)

    Kersting, S.
    Lincke, A.
    Drillich, M.
    Arlt, S.
    Heuwieser, W.
    38. Jahrestagung Physiologie und Pathologie der Fortpflanzung
    Zürich, 10. – 11.02.2005
    Schweizer Archiv für Tierheilkunde 147
    Bern: Hans Huber, 2005 — S. 64
    Tierklinik für Fortpflanzung

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    Abstract / Zusammenfassung

    Chronic endometritis is one of the most common reasons for infertility in dairy
    cows. The use of antibiotics, hormones and antiseptics is under critical
    discussion for different reasons. The need for innovative research is obvious. In
    this field trial, three protocols for the treatment of chronic endometritis were
    compared. The study was conducted on two diary herds, housing about 750
    diary cows each. Cows were examined 21 to 27 days postpartum (p.p.) by rectal
    palpation and vaginoscopy for signs of chronic endometritis. In Group A cows
    received an intrauterine treatment with 20 ml of a salve containing proteolytic
    enzymes trypsin (16mg), chymotrypsin (16mg) and papain (8mg)
    (Mastiveyxym®, Veyx-Pharma GmbH). In Group B cows were treated with
    0,5mg of cloprostenol (PGF Veyx forte®, Veyx-Pharma GmbH). Cows in Group
    C were treated with 20 ml of the identical salve as in Group A but without
    enzymes (Placebo). This group serves as a control if a successful treatment of
    cows in Group A is caused by the enzymes or any other mechanisms. Fourteen
    days after the first treatment all cow were examined and re-treated according to
    the protocol of their group. Animals with signs of endometritis were re-
    examined 49 to 55 days p.p. and, in the case of endometritis re-treated. The
    voluntary waiting period in both farms was set at 70 days p.p.
    Until November 2004, a total of 343 cows were enrolled in the study.
    Preliminary results show that clinical cure rate after two treatments is 65,5%,
    72,9% and 68,8% for cows in groups A, B and C, respectively. Enrollment will
    be continued until March 2005. Reproductive performance measures will be