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    Untersuchungen über die Induktion von Verhaltensabhängigkeitin bezug auf Alkohol bei verschiedene Rattenstämmen (2001)

    Art
    Hochschulschrift
    Autor
    Müller, Ralf Werner
    Quelle
    Berlin, 2001 — 125 Seiten
    Kontakt
    Institut für Tierschutz und Tierverhalten

    Königsweg 67
    Gebäude 21, 1. OG
    14163 Berlin
    +49 30 838 62901
    tierschutz@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    In two experiments we investigated the possibility to induce behavioral alcohol
    dependence in rats using a successful model established by Wolffgramm (1990) and
    Wolffgramm and Heyne(1995).In the first experiment male Wistar rats were treate
    d with three different treatments. One group of rats had the choice between two
    different alcohol concentrations and tapwater for 45 weeks, a second group of ra
    ts received only tapwater and a third group of rats received only alcohol during
    this period. After a period of 12 weeks of alcohol deprivation all groups had t
    he choice between alcoholic solutions and tapwater. In the last weeks of the exp
    eriment the alcohol solutions but not the tapwater was mixed with a bitter subst
    ance (quinine). No signs of behavioral alcohol dependence were noticed in the th
    ree different treatments of rats. None of the groups increased the consumed amou
    nt of alcohol during the course of the trial, even after the period of alcohol d
    eprivation the amount of alcohol consumed increased only a little. After the add
    ition of quinine the rats prefered mainly the tapwater to the alcohol.In the sec
    ond experiment six different strains of rats were used to examine whether the st
    rain used in experiment 1 affected fundamental the result. They were treated lik
    e the first group of rats in the first experiment (choice between tapwater and a
    lcohol, alcohol deprivation and retest with the choice between tapwater and alco
    hol, in the end mixed with quinine). All strains reacted similarly. The amount o
    f alcohol consumed decreased continuously in the period of free choice between a
    lcohol and water and very strongly in the period the alcohol was mixed with quin
    ine.Altogether the two experiments showed that the model used is not reliable to
    induce behavioral alcohol deprivation in these strains of rats.