Publikationsdatenbank

Untersuchungen über die Induktion von Verhaltensabhängigkeitin bezug auf Alkohol bei verschiedene Rattenstämmen (2001)

Art

Hochschulschrift

Autor

Müller, Ralf Werner

Quelle

Berlin, 2001 — 125 Seiten

Kontakt

Institut für Tierschutz, Tierverhalten und Versuchstierkunde

Königsweg 67
14163 Berlin
+49 30 838 61146
tierschutz@vetmed.fu-berlin.de

Abstract / Zusammenfassung

In two experiments we investigated the possibility to induce behavioral alcohol
dependence in rats using a successful model established by Wolffgramm (1990) and
Wolffgramm and Heyne(1995).In the first experiment male Wistar rats were treate
d with three different treatments. One group of rats had the choice between two
different alcohol concentrations and tapwater for 45 weeks, a second group of ra
ts received only tapwater and a third group of rats received only alcohol during
this period. After a period of 12 weeks of alcohol deprivation all groups had t
he choice between alcoholic solutions and tapwater. In the last weeks of the exp
eriment the alcohol solutions but not the tapwater was mixed with a bitter subst
ance (quinine). No signs of behavioral alcohol dependence were noticed in the th
ree different treatments of rats. None of the groups increased the consumed amou
nt of alcohol during the course of the trial, even after the period of alcohol d
eprivation the amount of alcohol consumed increased only a little. After the add
ition of quinine the rats prefered mainly the tapwater to the alcohol.In the sec
ond experiment six different strains of rats were used to examine whether the st
rain used in experiment 1 affected fundamental the result. They were treated lik
e the first group of rats in the first experiment (choice between tapwater and a
lcohol, alcohol deprivation and retest with the choice between tapwater and alco
hol, in the end mixed with quinine). All strains reacted similarly. The amount o
f alcohol consumed decreased continuously in the period of free choice between a
lcohol and water and very strongly in the period the alcohol was mixed with quin
ine.Altogether the two experiments showed that the model used is not reliable to
induce behavioral alcohol deprivation in these strains of rats.