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    Cortico-striatal communication in dystonic dtsz hamster brain slices (2003)

    Art
    Vortrag
    Autoren
    Köhling, R. E.
    Koch, U. R.
    Hamann, M.
    Richter, A.
    Kongress
    82. Jahrestagung der Deutschen Physiologischen Gesellschaft
    Bochum, 02. – 05.03.2003
    Quelle
    Pflügers Archiv : European journal of physiology; 445(Suppl.) — S. S28
    ISSN: 1432-2013
    Sprache
    Englisch
    Kontakt
    Institut für Pharmakologie und Toxikologie

    Koserstr. 20
    14195 Berlin
    +49 30 838 53221
    pharmakologie@vetmed.fu-berlin.de

    Abstract / Zusammenfassung

    Dystonias are frequent,often therapy-refractory movement
    disorders.Primary dystonias prevail,whose pathophysiology is
    unknown.Dystonic mutant dt sz hamsters represent a model for
    primary dystonia.In previous studies (a)striatal interneuron
    density was determined to be low,and spontaneous firing rates in
    striatal output neurons high and (b)sodium currents in output
    neurons were particularly resistant to pharmacological blockade.
    Here,we explored whether these phenomena impact on cortico-
    striatal communication.Evoked activity (neocortical afferent
    stim)was recorded intra-and extracellularly from the striatum in
    combined cortico-striatal slice preparations from dystonic and
    control animals.Extracellular recordings revealed a higher
    proportion of population spikes at saturating stimulation strength
    (80%vs.57%),a left-shift of the input/output curve (population
    spike amplitude 1.6 vs 1.0 mV),more frequent paired-pulse
    accentuation (54%vs.21%of slices)and LTP (75%vs.54%of
    slices after tetanic stiumlation)in slices from dystonic animals.
    Cellular properties as input resistance,time constant,resting
    membrane potential,action potential amplitude and firing patterns
    were not different between control and dt sz tissue.In conclusion,
    striatal responses to afferent stimulation showed a tendency
    towards a higher excitability level in dystonic hamster slices.