Publikationsdatenbank

Magnetresonanztomographische und histologische Untersuchungen zum biologischen und physikalischen Verhalten eines monomer stabilisierten superparamagnetischen Kontrastmittels für die Magnetresonanzangiographie am Modell der Ratte (2001)

Art

Hochschulschrift

Autor

Abramjuk, Claudia

Quelle

Berlin, 2001 — 148 Seiten

Verweise

URL (Volltext): http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000000518

Kontakt

Institut für Veterinär-Anatomie

Koserstr. 20
14195 Berlin
+49 30 838 75784
anatomie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The aim of the present study was to investigate a new, monomer-coated superparamagnetic contrast medium for magnetic resonance angiography. This was done by magnetic resonance imaging (MRI) and histologic examinations performed to characterize the contrast medium VSOP-C63 in the rat model. A total of 101 rats were examined to determine the optimal dose and the blood half-life as well as the distribution and degradation of the contrast medium in connection with a histopathologic evaluation.
The MRI results obtained with a high-resolution 3D FLASH sequence showed a prolonged intravascular signal increase for all dosages (15, 30, 45, 60, 75 and 90 mmol/kg body mass (BM)) tested in 36 rats. The observed signal increase allowed for even delineating small, second- and third-order vessels. Blood half-lives were found to be dose-dependant. Significant differences in signal increase among the dosages tested were observed for doses up to 75 mmol/kg BM. The dose of 90 mmol/kg BM produced an overdose effect which was superimposed on the signal-enhancing effect at the early time points. With a time-optimized acquisition technique, bolus injection of VSOP-C63 at a dose of 45 mmol/kg produces the same signal-enhancing effect in the aorta as the injection of 0.2 mmol Gd/kg (Magnevistý). This is due to the favorable R2-to-R1 ratio of VSOP-C63, which is 1.3 as determined at 37°C in 0.9% NaCl using a field strength of 0.47 T.
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