Publikationsdatenbank

Mucosal immune responses and intestinal microbiome associations in wild spotted hyenas (Crocuta crocuta) (2025)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Veloso Soares, Susana P.

Jarquín-Díaz, Victor H.

Veiga, Miguel M.

Karl, Stephan

Czirják, Gábor Á.

Weyrich, Alexandra

Metzger, Sonja

East, Marion L.

Hofer, Heribert (WE 13)

Heitlinger, Emanuel

Benhaiem, Sarah

Ferreira, Susana C. M.

Quelle

Communications biology

Bandzählung: 8

Heftzählung: 1

Seiten: Artikel 924 (13 Seiten)

ISSN: 2399-3642

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s42003-025-08243-0

DOI: 10.1038/s42003-025-08243-0

Pubmed: 40514454

Kontakt

Institut für Parasitologie und Tropenveterinärmedizin

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 62310
parasitologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Little is known about host-gut microbiome interactions within natural populations at the intestinal mucosa, the primary interface. We investigate associations between the intestinal microbiome and mucosal immune measures while controlling for host, social and ecological factors in 199 samples of 158 wild spotted hyenas (Crocuta crocuta) in the Serengeti National Park, Tanzania. We profile the microbiome composition using a multi-amplicon approach and measure faecal immunoglobulin A and mucin. Probabilistic models indicate that both immune measures predicted microbiome similarity among individuals in an age-dependent manner. These associations are the strongest within bacteria, intermediate within parasites, and weakest within fungi communities. Machine learning models accurately predicted both immune measures and identify the taxa driving these associations: symbiotic bacteria reported in humans and laboratory mice, unclassified bacteria, parasitic hookworms and fungi. These findings improve our understanding of the gut microbiome, its drivers, and interactions in wild populations under natural selection.