Publication Database

Brain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape (2025)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Dubey, Abhishek

Yamashita, Erika

Stangeland, Biljana

Abbas, Imane

Fooksman, David

Harris, Robert A.

Palmer, Gregory M.

Koba, Wade R.

Zhang, Jinghang

Himes, Benjamin T.

Lu, Olivia R.

Ho, Winson S.

Kuiper, Raoul V.

Huffman, Derek

Wu, Zhiping

Uchida, Yutaka

Ishii, Masaru

Welch, Rachel L.

Fiedler, Alexander F. (WE 2)

Reynolds, David

Hosainey, S. A. Mohieb

Dobrenis, Kostantin

Ye, Qinge

Fisher, Kevin

Killian, Nathaniel

Stanley, E. Richard

Eskandar, Emad

Behnan, Jinan

Quelle

Nature neuroscience

Bandzählung: 28

Heftzählung: 11

Seiten: 2231 – 2246

ISSN: 1097-6256

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s41593-025-02064-4

DOI: 10.1038/s41593-025-02064-4

Pubmed: 41044343

Kontakt

Institut für Veterinär-Physiologie

Oertzenweg 19 b
14163 Berlin
+49 30 838 62600
physiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The skull marrow niche has recently been identified as a reservoir that supplies the brain with monocytes and neutrophils in the context of disease and injury, but its role in brain cancers remains unknown. Here we show that glioblastoma, the most malignant type of brain tumor, induces calvarial bone abnormalities in murine models and patients with glioblastoma, altering osteoclast activities and increasing the number of skull channels in mice. Single-cell RNA sequencing revealed glioblastoma-mediated alterations in the immune landscape of skull marrow and femoral bone marrow, including expansion of neutrophils and deterioration of various B cell subsets. In vivo inhibition of bone resorption reduced bone abnormalities, but promoted tumor progression in mesenchymal subtype tumors. This also abolished the survival benefit of the checkpoint inhibitor anti-PD-L1, by reducing activated T cell and increasing inflammatory neutrophil numbers. Together, these data provide insight into how brain tumors affect skull bone and the immune environment.