Publikationsdatenbank

Porcine lymphotropic herpesvirus (PLHV) was not transmitted during transplantation of genetically modified pig hearts into baboons (2025)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Jhelum, Hina (WE 5)

Bender, Martin

Reichart, Bruno

Abicht, Jan-Michael

Längin, Matthias

Kaufer, Benedikt B. (WE 5)

Denner, Joachim (WE 5)

Quelle

International journal of molecular sciences

Bandzählung: 26

Heftzählung: 15

Seiten: 7378

ISSN: 1422-0067

Sprache

Englisch

Verweise

URL (Volltext): https://www.mdpi.com/1422-0067/26/15/7378

DOI: 10.3390/ijms26157378

Pubmed: 40806506

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Porcine lymphotropic herpesviruses -1, -2, and -3 (PLHV-1, PLHV-2, and PLHV-3) are gammaherpesviruses that are widespread in pigs. These viruses are closely related to the human pathogens Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV), both of which are known to cause severe diseases in humans. To date, however, no definitive association has been established between PLHVs and any disease in pigs. With the growing interest in xenotransplantation as a means to address the shortage of human organs for transplantation, the safety of using pig-derived cells, tissues, and organs is under intense investigation. In preclinical trials involving pig-to-nonhuman primate xenotransplantation, another porcine herpesvirus-porcine cytomegalovirus, a porcine roseolovirus (PCMV/PRV)-was shown to be transmissible and significantly reduced the survival time of the xenotransplants. In the present study, we examined donor pigs and their respective baboon recipients, all of which were part of preclinical pig heart xenotransplantation studies, for the presence of PLHV. PLHV-1, PLHV-2, and PLHV-3 were detected in nearly all donor pigs; however, no evidence of PLHV transmission to the baboon recipients was observed.