Publikationsdatenbank

Atypical mitochondrial phenotype of colonic CD4+ and CD8+ T cells during experimental chronic colitis (2025)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Negele, Jonas

Franz, Tobias

Krone, Anna

Roder, Marc

Gelmez, Elif

Jantz-Naeem, Nouria

Kershaw, Olivia (WE 12)

Keitel-Anselmino, Verena

Jeron, Andreas

Bruder, Dunja

Kahlfuß, Sascha

Quelle

Biomedicines : open access journal

Bandzählung: 13

Heftzählung: 9

Seiten: 2094

ISSN: 2227-9059

Sprache

Englisch

Verweise

URL (Volltext): https://www.mdpi.com/2227-9059/13/9/2094

DOI: 10.3390/biomedicines13092094

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background: Patients with ulcerative colitis (UC) suffer from a chronic relapsing-remitting inflammatory bowel disease and show heterogeneous disease severity and therapy response. It was recently reported that rectal biopsies from patients with UC show a downregulation of various mitochondrial genes during active UC. Methods: We used dextran sulfate sodium (DSS)-induced colitis as a preclinical mouse model for UC to study metabolic characteristics of ex vivo colonic lamina propria CD4+ and CD8+ T cells, B cells, eosinophils, neutrophils and intestinal epithelial cells during experimental acute and chronic inflammatory bowel disease and remission state. Results: Our results indicate that CD4+ and CD8+ T cells in the colon produce significantly less mitochondrial reactive oxygen species and possess smaller mitochondria during chronic DSS-induced colitis, which is resolved during remission state. In addition, CD4+ and CD8+ T cells exhibit increased glucose uptake during acute but defective glucose consumption during chronic DSS colitis. Conclusions: Together, our data provide evidence for an atypical mitochondrial phenotype of colonic CD4+ and CD8+ T cells during chronic colitis that is resolved during the remission phase of the disease.