Publikationsdatenbank

Neurolymphomatosis of T-cell origin in a dog (2025)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Müller, Marie-Kerstin

Irmscher, Michaela

Goldbach, Nadja

Haake, Alexander (WE 12)

Kershaw, Olivia (WE 12)

Baloi, Penelope A.

Quelle

Journal of veterinary internal medicine

Bandzählung: 39

Heftzählung: 4

Seiten: e70189

ISSN: 0891-6640

Sprache

Englisch

Verweise

URL (Volltext): https://onlinelibrary.wiley.com/doi/10.1111/jvim.70189

DOI: 10.1111/jvim.70189

Pubmed: 40702997

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

A 10-year-old mixed-breed dog was presented with progressive neurological deficits suggestive of polyneuropathy. CT and MRI revealed no relevant abnormalities, whereas the CSF analysis showed a marked lymphocytic pleocytosis, immunocytochemically classified as T-cell lymphoma. Chemotherapy ensued with no improvement of clinical signs. Cerebrospinal fluid reanalysis still revealed a mild lymphocytic pleocytosis. MRI of the brain and spinal cord solely showed a reduced ventral subarachnoid and epidural space (Th11-L2) and mild enlargement of the central canal in this area. Postmortem examination revealed thickening of the spinal nerve roots and ganglia. Histologically, a marked intraspinal-subdural and intraneural, as well as intra-ganglionic, infiltration by large lymphocytes in the peripheral nervous system was visible. Immunohistochemically, the infiltrating lymphoblasts were CD3 positive, confirming T-cell origin. Neurolymphomatosis is a rarely described neoplastic disease in dogs. The present case highlights the importance of analysis of CSF in neurologically abnormal dogs.