Publikationsdatenbank

Efficacy of 0.2% povidone-iodine and 0.1% polyhexamethylene biguanide as preoperative antiseptics in equine ophthalmic procedures (2025)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Farkas, Anna (WE 19)

Thieme, Katharina (WE 19)

Soimala, Tanawan

Jensen, Charlotte K.

Eule, J. Corinna (WE 19)

Quelle

Veterinary Ophthalmology : an international journal of clinical and investigative ophthalmology

Bandzählung: 28

Heftzählung: 2

Seiten: 438 – 447

ISSN: 1463-5216

Sprache

Englisch

Verweise

URL (Volltext): https://onlinelibrary.wiley.com/doi/epdf/10.1111/vop.13306

DOI: 10.1111/vop.13306

Pubmed: 39648293

Kontakt

Tierklinik für Fortpflanzung

Königsweg 65
Haus 27
14163 Berlin
+49 30 838 62618
fortpflanzungsklinik@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Objective: This retrospective study evaluates the efficacy of povidone-iodine (PI) and polyhexamethylene biguanide (PHMB) as preoperative antiseptics in equine ophthalmic procedures.
Animals Studied: Horses that underwent routine ophthalmic surgery and procedures.
Procedures: Data were collected retrospectively from the medical records of equine patients undergoing ophthalmic procedures. Inclusion criteria were
sampling for aerobic microbial culture at three different time points (T0: preirrigation, T1: post-irrigation, and T2: postoperatively) and T0 showing bacterial
growth. Microbiological outcomes were assessed semi-quantitatively by creating a scoring system to describe the bacterial load. Furthermore, the species detected were evaluated. Poisson regression analysis was performed to evaluate the efficacy of the disinfectants.
Results: Eighty eyes (75 horses) met the inclusion criteria, with 36 cases being aseptically prepared with PI and 44 with PHMB. Both antiseptics significantly reduced the bacterial load and number of bacterial species (p < .001) between time points T0 and T1, and T0 and T2. PHMB showed a reduction in the bacterial load by 64% (CI: 51%–73%) whereas PI reduced it by 48% (CI: 36%–58%) between time points T0 and T1. The reduction in the number of bacterial species between time points T0 to T1 was significantly greater in the PHMB group (85%, CI: 70%–93%), compared to PI (47%, CI: 26%–62%).
Conclusion: Both PHMB and PI reduced the bacterial load and number of species on the ocular surface and eyelids significantly, with 0.1% PHMB being
superior to 0.2% PI. Therefore, PHMB can be considered as a good alternative in preoperative antisepsis in equine ophthalmic procedures.