Publikationsdatenbank

Characterization of anthracycline-induced cardiotoxicity by diffusion tensor magnetic resonance imaging (2025)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Lohr, David

Thiele, Arne

Stahnke, Max

Braun, Vera M.

Klopfleisch, Robert (WE 12)

Klein, Oliver

Dresen, Sandra

Landmesser, Ulf

Foryst-Ludwig, Anna

Kintscher, Ulrich

Schreiber, Laura M.

Beyhoff, Niklas

Quelle

Basic Research in Cardiology : official journal of the German Cardiac Society

Bandzählung: 120

Heftzählung: 1

Seiten: 57 – 69

ISSN: 1435-1803

Sprache

Englisch

Verweise

URL (Volltext): https://link.springer.com/article/10.1007/s00395-024-01039-z

DOI: 10.1007/s00395-024-01039-z

Pubmed: 38483601

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Anthracyclines are highly potent anti-cancer drugs, but their clinical use is limited by severe cardiotoxic side effects. The impact of anthracycline-induced cardiotoxicity (AIC) on left ventricular (LV) microarchitecture and diffusion properties remains unknown. This study sought to characterize AIC by cardiovascular magnetic resonance diffusion tensor imaging (DTI). Mice were treated with Doxorubicin (DOX; n = 16) for induction of AIC or saline as corresponding control (n = 15). Cardiac function was assessed via echocardiography at the end of the study period. Whole hearts (n = 8 per group) were scanned ex vivo by high-resolution DTI at 7 T. Results were correlated with histopathology and mass spectrometry imaging. Mice with AIC demonstrated systolic dysfunction (LVEF 52 ± 3% vs. 43 ± 6%, P < 0.001), impaired global longitudinal strain (−19.6 ± 2.0% vs. −16.6 ± 3.0%, P < 0.01), and cardiac atrophy (LV mass index [mg/mm], 4.3 ± 0.1 vs. 3.6 ± 0.2, P < 0.01). Regional sheetlet angles were significantly lower in AIC, whereas helix angle and relative helicity remained unchanged. In AIC, fractional anisotropy was increased (0.12 ± 0.01 vs. 0.14 ± 0.02, P < 0.05). DOX-treated mice displayed higher planar and less spherical anisotropy (CPlanar 0.07 ± 0.01 vs. 0.09 ± 0.01, P < 0.01; CSpherical 0.89 ± 0.01 vs. 0.87 ± 0.02, P < 0.05). CPlanar and CSpherical yielded good discriminatory power to distinguish between mice with and without AIC (c-index 0.91 and 0.84, respectively, P for both < 0.05). AIC is associated with regional changes in sheetlet angle but no major abnormalities of global LV microarchitecture. The geometric shape of the diffusion tensor is altered in AIC. DTI may provide a new tool for myocardial characterization in patients with AIC, which warrants future clinical studies to evaluate its diagnostic utility.