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Detection of “beaver leukocidin”-positive Staphylococcus aureus and diphtheria toxin-positive Corynebacterium ulcerans in Eurasian beavers from Germany (2024)

Art

Vortrag

Autoren

Mühldorfer, K.

Monecke, S.

Ehricht, R.

Sing, A.

Berger, A.

Dangel, A.

Wibbelt, G.

Krüger-Haker, H. (WE 7)

Hanke, D. (WE 7)

Feßler, A. T. (WE 7)

Schwarz, S. (WE 7)

Kongress

6th International Conference of the European College of Veterinary Microbiology

University of Nottingham, UK, 05. – 07.09.2024

Quelle

Scientific abstracts : 6th International Conference of the European College of Veterinary Microbiology : 5th – 6th September 2024, University of Nottingham, UK

— S. 21

Sprache

Englisch

Verweise

URL (Volltext): https://cdn-eu.eventscase.com/clearwaterevents.eventscase.com/uploads/users/971808/uploads/83159d715ef64b1ca7f9eed01d78e14dcba7cbd9231f1adb81e36986efa9d1aa5ff13e3bf142f1b140448156ca2784a07c89.66d813278d10c.pdf

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Objectives: Although considered as source of zoonotic pathogens wildlife animals also suffer health consequences from emerging pathogens. Here, we report Staphylococcus aureus and Corynebacterium ulcerans infections in beavers with purulent lesions and abscesses.
Methods: Between 2015 and 2024, twenty-one S. aureus and two C. ulcerans were collected from fourteen beavers and investigated for their antimicrobial resistance and genotypic virulence properties. Expression of Panton-Valentine leucocidin (PVL) in S. aureus and toxin production in C. ulcerans were determined by PVL lateral flow device and modified Elek test, respectively.
Results: So far, eleven S. aureus isolates have been further characterized. The most common spa type was t3058, all belonging to clonal complex (CC) 1956, while t208 and CC49 were identified only once. Interestingly, all S. aureus carry and express beaver-specific variants of the PVL genes (lukS-BV; lukF-BV). Both C. ulcerans isolates belonged to sequence type (ST)332, carrying and expressing the diphtheria toxin gene. S. aureus isolates were susceptible to all antimicrobials tested and negative for the respective resistance genes. Both C. ulcerans were only clindamycin resistant.
Conclusions: We found that S. aureus isolated from fatally diseased beavers harbour distinct lukS/F genes, which are closely related to the PVL genes from humans and induce the same pathology in beavers as PVL-positive S. aureus in humans. Both C. ulcerans are classified as toxigenic and ST332, which was rarely found in beavers, hedgehogs and humans. These results indicate a more common occurrence of these pathogens with a possible risk of zoonotic transmission between wildlife and humans.