Publikationsdatenbank

Sulfated cellulose nanofiber hydrogel with mucus-like activities for virus inhibition (2024)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Long, Yanping

Dimde, Mathias

Adler, Julia M. (WE 11)

Vidal, Ricardo Martin (WE 5)

Povolotsky, Tatyana L.

Nickl, Philip

Achazi, Katharina

Trimpert, Jakob (WE 5)

Kaufer, Benedikt B. (WE 5)

Haag, Rainer

Nie, Chuanxiong

Quelle

ACS applied materials & interfaces / American Chemical Society

Bandzählung: 16

Heftzählung: 49

Seiten: 67504 – 67513

ISSN: 1944-8244

Sprache

Englisch

Verweise

URL (Volltext): https://pubs.acs.org/doi/10.1021/acsami.4c17998

DOI: 10.1021/acsami.4c17998

Pubmed: 39582136

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Mucus is the first defense barrier against viruses in the human immune system. Inspired by the mucus structure, we designed a highly sulfated hydrogel to bind viruses and prevent infection of the underlying cells. The hydrogel was formed by gelation of sulfated cellulose nanofiber (SCNF) with Ca2+. SCNF exhibited a mucin-like nanofiber structure with high numbers of sulfated groups. Based on the electrostatic interactions with a virus, SCNF could efficiently inhibit herpes simplex virus-1 (HSV-1) infection with a half-maximal inhibitory concentration (IC50) of 0.43 μg/mL, which is comparable to that of heparin (IC50 = 0.30 μg/mL). Benefiting from the multiporous structure and sulfate groups, the Ca2+-SCNF hydrogel could efficiently trap HSV-1 and inhibit the virus from attacking the underlying cells in a transwell model. Furthermore, SCNF also inhibited SARS-CoV-2 infection in a similar experimental setting. By integrating the advantages of high and broad-spectrum virus inhibitory activity as well as low toxicity, it is believed that the Ca2+-SCNF hydrogel can promote the development of highly biocompatible and efficient antiviral material with “binding and inhibition” capability and other diverse strategies.