Publikationsdatenbank

The transmission risk of multidrug-resistant organisms between hospital patients and their pets:
a case-control study, Germany, 2019 to 2022 (2024)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Hackmann, Carolin

Genath, Antonia

Gruhl, Désirée

Weber, Anna

Maechler, Friederike

Kola, Axel

Schwab, Frank

Schwarz, Stefan (WE 7)

Lübke-Becker, Antina (WE 7)

Schneider, Thomas

Gastmeier, Petra

Leistner, Rasmus

Quelle

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Bandzählung: 29

Heftzählung: 39

Seiten: 2300714

ISSN: 1560-7917

Sprache

Englisch

Verweise

URL (Volltext): https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2024.29.39.2300714

DOI: 10.2807/1560-7917.ES.2024.29.39.2300714

Pubmed: 39328155

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background: Carriage of multidrug-resistant organisms (MDROs) in humans constitutes an important public health concern. Cross-transmission of bacteria between animals and humans has been demonstrated before.AimOur aim was to quantify the risk factor 'pet ownership' for MDRO colonisation in hospital patients.MethodsWe performed a matched case-control study from 2019 to 2022 in Berlin, Germany and compared MDRO-positive and MDRO-negative patients in terms of contact with pets and other risk factors for MDRO acquisition. Patients completed a questionnaire-based interview and provided nasal and rectal swabs. Pet owners provided swab samples from the throat and stool of their pets (dogs and cats). Phenotypically matching samples of owners and pets were analysed via whole genome sequencing.
Results: The analyses included 2,891 patients. Reported pet ownership was 17.7% in MDRO-positives (154/871) and 23.4% in MDRO-negatives (472/2,020). Among 397 owner-pet pairs, we identified one pair sharing genotypically indistinguishable pathogens (0.3%). A risk factor analysis of pet ownership was performed for carriers of meticillin-resistant Staphylococcus aureus (MRSA) (OR = 0.662; 95% CI: 0.343-1.277), vancomycin-resistant enterococci (VRE) (OR = 0.764; 95% CI: 0.522-1.118) and multidrug-resistant Gram-negative bacteria (MDR-GNB) (OR = 0.819; 95% CI: 0.620-1.082). Colonisation with MDRO was rare in pets, and dogs were more often colonised than cats (MRSA: 0% vs 0%, VRE: 1.5% vs 1.0%, MDR-GNB: 17.2% vs 3.6%).
Conclusion: Transmission of MDROs between humans and pets is possible though rare. In an urban living space, neither cat nor dog ownership appears as a relevant risk factor for MDRO carriage in hospital patients.