Publikationsdatenbank

The endothelial glycocalyx in pig-to-baboon cardiac xenotransplantation:
first insights (2024)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Bender, Martin

Abicht, Jan-Michael

Reichart, Bruno

Leuschen, Maria

Wall, Felicia

Radan, Julia

Neumann, Elisabeth

Mokelke, Maren

Buttgereit, Ines

Michel, Sebastian

Ellgass, Reinhard

Gieseke, Katja

Steen, Stig

Paskevicius, Audrius

Denner, Joachim (WE 5)

Godehardt, Antonia W.

Tönjes, Ralf R.

Hagl, Christian

Ayares, David

Wolf, Eckhard

Schmoeckel, Michael

Brenner, Paolo

Müller, Martin B.

Längin, Matthias

Quelle

Biomedicines : open access journal

Bandzählung: 12

Heftzählung: 6

Seiten: 1336

ISSN: 2227-9059

Sprache

Englisch

Verweise

URL (Volltext): https://www.mdpi.com/2227-9059/12/6/1336

DOI: 10.3390/biomedicines12061336

Pubmed: 38927543

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation. Despite these achievements, acute vascular rejection still presents a challenge for long-term xenograft acceptance and new insights into innate and adaptive immune responses as well as detailed characterizations of signaling pathways are necessary. In allotransplantation, endothelial cells and their sugar-rich surface-the endothelial glycocalyx-are known to influence organ rejection. In xenotransplantation, however, only in vitro data exist on the role of the endothelial glycocalyx so far. Thus, in the current study, we analyzed the changes of the endothelial glycocalyx components hyaluronan, heparan sulfate and syndecan-1 after pig-to-baboon cardiac xenotransplantations in the perioperative (n = 4) and postoperative (n = 5) periods. These analyses provide first insights into changes of the endothelial glycocalyx after pig-to-baboon cardiac xenotransplantation and show that damage to the endothelial glycocalyx seems to be comparable or even less pronounced than in similar human settings when current strategies of cardiac xenotransplantation are applied. At the same time, data from the experiments where current strategies, like non-ischemic preservation, growth inhibition or porcine cytomegalovirus (a porcine roseolovirus (PCMV/PRV)) elimination could not be applied indicate that damage of the endothelial glycocalyx also plays an important role in cardiac xenotransplantation.