Publikationsdatenbank

LDL receptor in alphavirus entry:
structural analysis and implications for antiviral therapy (2024)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Wang, Ningning

Merits, Andres

Veit, Michael (WE 5)

Lello, Laura Sandra

Kong, Shuhan

Jiao, Houqi

Chen, Jie

Wang, Yu

Dobrikov, Georgi

Rey, Félix A.

Su, Shuo

Quelle

Nature Communications

Bandzählung: 15

Heftzählung: 1

Seiten: 4906

ISSN: 2041-1723

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s41467-024-49301-1

DOI: 10.1038/s41467-024-49301-1

Pubmed: 38851803

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses