Publikationsdatenbank

Koala retrovirus and neoplasia:
correlation and underlying mechanisms (2024)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Tarlinton, Rachael

Greenwood, Alex D. (WE 12)

Quelle

Current opinion in virology

Bandzählung: 67

Seiten: 101427

ISSN: 1879-6265

Sprache

Englisch

Verweise

URL (Volltext): https://linkinghub.elsevier.com/retrieve/pii/S1879625724000415

DOI: 10.1016/j.coviro.2024.101427

Pubmed: 39047314

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The koala retrovirus, KoRV, is one of the few models for understanding the health consequences of retroviral colonization of the germline. Such colonization events transition exogenous infectious retroviruses to Mendelian traits or endogenous retroviruses (ERVs). KoRV is currently in a transitional state from exogenous retrovirus to ERV, which in koalas (Phascolarctos cinereus) has been associated with strongly elevated levels of neoplasia. In this review, we describe what is currently known about the associations and underlying mechanisms of KoRV-induced neoplasia.