Publikationsdatenbank

Lethal Borna disease virus 1 infections of humans and animals – in-depth molecular epidemiology and phylogeography (2024)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Ebinger, Arnt

Santos, Pauline D.

Pfaff, Florian

Dürrwald, Ralf

Kolodziejek, Jolanta

Schlottau, Kore

Ruf, Viktoria

Liesche-Starnecker, Friederike

Ensser, Armin

Korn, Klaus

Ulrich, Reiner

Fürstenau, Jenny (WE 12)

Matiasek, Kaspar

Hansmann, Florian

Seuberlich, Torsten

Nobach, Daniel

Müller, Matthias

Neubauer-Juric, Antonie

Suchowski, Marcel

Bauswein, Markus

Niller, Hans-Helmut

Schmidt, Barbara

Tappe, Dennis

Cadar, Daniel

Homeier-Bachmann, Timo

Haring, Viola C.

Pörtner, Kirsten

Frank, Christina

Mundhenk, Lars (WE 12)

Hoffmann, Bernd

Herms, Jochen

Baumgärtner, Wolfgang

Nowotny, Norbert

Schlegel, Jürgen

Ulrich, Rainer G.

Beer, Martin

Rubbenstroth, Dennis

Quelle

Nature Communications

Bandzählung: 15

Heftzählung: 1

Seiten: 7908

ISSN: 2041-1723

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s41467-024-52192-x

DOI: 10.1038/s41467-024-52192-x

Pubmed: 39256401

Kontakt

Institut für Tierpathologie

Robert-von-Ostertag-Str. 15
14163 Berlin
+49 30 838 62450
pathologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Borna disease virus 1 (BoDV-1) is the causative agent of Borna disease, a fatal neurologic disorder of domestic mammals and humans, resulting from spill-over infection from its natural reservoir host, the bicolored white-toothed shrew (Crocidura leucodon). The known BoDV-1-endemic area is remarkably restricted to parts of Germany, Austria, Switzerland and Liechtenstein. To gain comprehensive data on its occurrence, we analysed diagnostic material from suspected BoDV-1-induced encephalitis cases based on clinical and/or histopathological diagnosis. BoDV-1 infection was confirmed by RT-qPCR in 207 domestic mammals, 28 humans and seven wild shrews. Thereby, this study markedly raises the number of published laboratory-confirmed human BoDV-1 infections and provides a first comprehensive summary. Generation of 136 new BoDV-1 genome sequences from animals and humans facilitated an in-depth phylogeographic analysis, allowing for the definition of risk areas for zoonotic BoDV-1 transmission and facilitating the assessment of geographical infection sources. Consistent with the low mobility of its reservoir host, BoDV-1 sequences showed a remarkable geographic association, with individual phylogenetic clades occupying distinct areas. The closest genetic relatives of most human-derived BoDV-1 sequences were located at distances of less than 40 km, indicating that spill-over transmission from the natural reservoir usually occurs in the patient´s home region.