Publication Database

Concurrent Ascaris infection modulates host immunity resulting in impaired control of Salmonella infection in pigs (2024)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Midha, Ankur (WE 6)

Oser, Larissa (WE 6)

Schlosser-Brandenburg, Josephine (WE 6)

Laubschat, Alexandra (WE 6)

Mugo, Robert M. (WE 6)

Musimbi, Zaneta D. (WE 6)

Höfler, Philipp (WE 6)

Kundik, Arkadi (WE 6)

Hayani, Rima (WE 6)

Adjah, Joshua (WE 6)

Groenhagen, Saskia (WE 6)

Tieke, Malte (WE 6)

Elizalde-Velázquez, Luis E. (WE 6)

Kühl, Anja A.

Klopfleisch, Robert (WE 12)

Tedin, Karsten (WE 7)

Rausch, Sebastian (WE 6)

Hartmann, Susanne (WE 6)

Quelle

mSphere

Seiten: e00478-24

ISSN: 2379-5042

Sprache

Englisch

Verweise

URL (Volltext): https://journals.asm.org/doi/10.1128/msphere.00478-24

DOI: 10.1128/msphere.00478-24

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Ascaris is one of the most widespread helminth infections, leading to chronic morbidity in humans and considerable economic losses in pig farming. In
addition, pigs are an important reservoir for the zoonotic salmonellosis, where pigs can serve as asymptomatic carriers. Here, we investigated the impact of an ongoing Ascaris infection on the immune response to Salmonella in pigs. We observed higher bacterial burdens in experimentally coinfected pigs compared to pigs infected with Salmonella alone. The impaired control of Salmonella in the coinfected pigs was associated with
repressed interferon gamma responses in the small intestine and with the alternative activation of gut macrophages evident in elevated CD206 expression. Ascaris single and coinfection were associated with a rise of CD4-CD8α+FoxP3+ Treg in the lymph nodes draining the small intestine and liver. In addition, macrophages from coinfected pigs showed enhanced susceptibility to Salmonella infection in vitro and the Salmonella-induced monocytosis and tumor necrosis factor alpha production by myeloid cells was repressed in pigs coinfected with Ascaris. Hence, our data indicate that acute Ascaris infection modulates different immune effector functions with important consequences for the control of tissue-invasive coinfecting pathogens.