Publikationsdatenbank

The neonatal southern white rhinoceros ovary contains oogonia in germ cell nests (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Appeltant, Ruth

Hermes, Robert

Holtze, Susanne

Modina, Silvia Clotilde

Galli, Cesare

Bjarkadottir, Briet. D.

Adeniran, Babatomisin V.

Wei, Xi

Swegen, Aleona

Hildebrandt, Thomas B (WE 18)

Williams, Suzannah A.

Quelle

Communications biology

Bandzählung: 6

Heftzählung: 1

Seiten: Artikelnummer: 1049

ISSN: 2399-3642

Sprache

Englisch

Verweise

URL (Volltext): https://www.nature.com/articles/s42003-023-05256-5

DOI: 10.1038/s42003-023-05256-5

Pubmed: 37848538

Kontakt

Nutztierklinik

Königsweg 65
14163 Berlin
+49 30 838 62261
klauentierklinik@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The northern white rhinoceros is functionally extinct with only two females left. Establishing methods to culture ovarian tissues, follicles, and oocytes to generate eggs will support conservation efforts using in vitro embryo production. To the best of our knowledge, this is the first description of the structure and molecular signature of any rhinoceros, more specifically, we describe the neonatal and adult southern white rhinoceros (Ceratotherium simum simum) ovary; the closest relation of the northern white rhinoceros. Interestingly, all ovaries contain follicles despite advanced age. Analysis of the neonate reveals a population of cells molecularly characterised as mitotically active, pluripotent with germ cell properties. These results indicate that unusually, the neonatal ovary still contains oogonia in germ cell nests at birth, providing an opportunity for fertility preservation. Therefore, utilising ovaries from stillborn and adult rhinoceros can provide cells for advanced assisted reproductive technologies and investigating the neonatal ovaries of other endangered species is crucial for conservation.