Publication Database

Wildlife endogenous retroviruses:
colonization, consequences, and cooption (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Jern, Patric

Greenwood, A. D. (WE 5)

Quelle

Trends in genetics

Bandzählung: 40

Heftzählung: 2

Seiten: 149 – 159

ISSN: 0168-9525

Sprache

Englisch

Verweise

URL (Volltext): https://pubmed.ncbi.nlm.nih.gov/37985317/

DOI: 10.1016/j.tig.2023.10.014

Pubmed: 37985317

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Endogenous retroviruses (ERVs) are inherited genomic remains of past germline retroviral infections. Research on human ERVs has focused on medical implications of their dysregulation on various diseases. However, recent studies incorporating wildlife are yielding remarkable perspectives on long-term retrovirus-host interactions. These initial forays into broader taxonomic analysis, including sequencing of multiple individuals per species, show the incredible plasticity and variation of ERVs within and among wildlife species. This demonstrates that stochastic processes govern much of the vertebrate genome. In this review, we elaborate on discoveries pertaining to wildlife ERV origins and evolution, genome colonization, and consequences for host biology.