Publikationsdatenbank

Newly identified lineages of porcine hemagglutinating Encephalomyelitis virus exhibit respiratory phenotype (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

He, Wan-Ting

Li, Dongyan

Baele, Guy

Zhao, Jin

Jiang, Zhiwen

Ji, Xiang

Veit, Michael (WE 5)

Suchard, Marc A.

Holmes, Edward C.

Lemey, Philippe

Boni, Maciej F.

Su, Shuo

Quelle

Virus evolution

Bandzählung: 9

Heftzählung: 2

Seiten: vead051

ISSN: 2057-1577

Sprache

Englisch

Verweise

URL (Volltext): https://pubmed.ncbi.nlm.nih.gov/37711483/

DOI: 10.1093/ve/vead051

Pubmed: 37711483

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Swine pathogens have a long history of zoonotic transmission to humans, occasionally leading to sustained outbreaks or pandemics. Through a retrospective epidemiological study of swine populations in China, we describe novel lineages of porcine hemagglutinating encephalomyelitis virus (PHEV) complex coronaviruses (CoVs) that cause exclusively respiratory symptoms with no signs of the neurological symptoms typically associated with classical PHEV infection. Through large-scale epidemiological surveillance, we show that these novel lineages have circulated in at least eight provinces in southeastern China. Phylogenetic and recombination analyses of twenty-four genomes identified two major viral lineages causing respiratory symptoms with extensive recombination within them, between them, and between classical PHEV and the novel respiratory variant PHEV (rvPHEV) lineages. Divergence times among the sampled lineages in the PHEV virus complex date back to 1886-1958 (mean estimate 1928), with the two major rvPHEV lineages separating approximately 20 years later. Many rvPHEV viruses show amino acid substitutions at the carbohydrate-binding site of hemagglutinin esterase (HE) and/or have lost the cysteine required for HE dimerization. This resembles the early adaptation of human CoVs, where HE lost its hemagglutination ability to adapt to growth in the human respiratory tract. Our study represents the first report of the evolutionary history of rvPHEV circulating in swine and highlights the importance of characterizing CoV diversity and recombination in swine to identify pathogens with outbreak potential that could threaten swine farming.