Publikationsdatenbank

Current status of cardiac xenotransplantation:
report of a Workshop of the German Heart Transplant Centers, Martinsried, March 3, 2023 (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Schmoeckel, Michael

Längin, Matthias

Reichart, Bruno

Abicht, Jan-Michael

Bender, Martin

Michel, Sebastian

Kamla, Christine-Elena

Denner, Joachim (WE 5)

Tönjes, Ralf Reinhard

Schwinzer, Reinhard

Marckmann, Georg

Wolf, Eckhard

Brenner, Paolo

Hagl, Christian

Quelle

The Thoracic and cardiovascular surgeon

Bandzählung: 72

Heftzählung: 4

Seiten: 273 – 284

ISSN: 1439-1902

Sprache

Englisch

Verweise

URL (Volltext): https://pubmed.ncbi.nlm.nih.gov/38154473/

DOI: 10.1055/a-2235-8854

Pubmed: 38154473

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

This report comprises the contents of the presentations and following discussions of a workshop of the German Heart Transplant Centers in Martinsried, Germany on cardiac xenotransplantation. The production and current availability of genetically modified donor pigs, preservation techniques during organ harvesting, and immunosuppressive regimens in the recipient are described. Selection criteria for suitable patients and possible solutions to the problem of overgrowth of the xenotransplant are discussed. Obviously microbiological safety for the recipient and close contacts is essential, and ethical considerations to gain public acceptance for clinical applications are addressed. The first clinical trial will be regulated and supervised by the Paul-Ehrlich-Institute as the National Competent Authority for Germany, and the German Heart Transplant Centers agreed to cooperatively select the first patients for cardiac xenotransplantation.