Publikationsdatenbank

Attenuation of viruses by large-scale recoding of their genomes:
the selection is always biased (2018)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Osterrieder, Klaus (WE 5)

Kunec, Dusan (WE 5)

Quelle

Current clinical microbiology reports

Bandzählung: 5

Heftzählung: 1

Seiten: 66 – 72

ISSN: 2196-5471

Sprache

Englisch

Verweise

URL (Volltext): https://pubmed.ncbi.nlm.nih.gov/32226716/

DOI: 10.1007/s40588-018-0080-3

Pubmed: 32226716

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Purpose of reviews:
This review summarizes the current understanding of virus attenuation by large-scale recoding of viral genomes and discusses what would ultimately be necessary for construction of better and safer live modified virus vaccines.

Recent findings:
It has been shown that codon and codon pair deoptimization are rapid and robust methods that can be used for the development of attenuated vaccine candidates. The viruses attenuated by large-scale recoding have the added value that they are extremely genetically stable. However, the exact mechanisms that lead to viral attenuation by recoding are yet to be determined.

Summary:
While the advantages of large-scale recoding (speed, simplicity, potency, and universal applicability) have been known for more than a decade, this approach has been only inadequately explored and the attention was focused on a limited number of RNA viruses. Attenuation of viruses by large-scale recoding should be explored to combat known and future viral threats.