Publikationsdatenbank

Delineating the seasonality of Varicella and its association with climate in the tropical country of Colombia (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Barrero Guevara, Laura Andrea

Goult, Elizabeth

Rodriguez, Dayanne

Hernandez, Luis Jorge

Kaufer, Benedikt (WE 5)

Kurth, Tobias

Domenech de Cellès, Matthieu

Quelle

The Journal of infectious diseases

Bandzählung: 228

Heftzählung: 6

Seiten: 674 – 683

ISSN: 0022-1899

Sprache

Englisch

Verweise

URL (Volltext): https://pubmed.ncbi.nlm.nih.gov/37384795/

DOI: 10.1093/infdis/jiad244

Pubmed: 37384795

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background:
Varicella causes a major health burden in many low- to middle-income countries located in tropical regions. Because of the lack of surveillance data, however, the epidemiology of varicella in these regions remains uncharacterized. In this study, based on an extensive dataset of weekly varicella incidence in children ≤10 during 2011-2014 in 25 municipalities, we aimed to delineate the seasonality of varicella across the diverse tropical climates of Colombia.

Methods:
We used generalized additive models to estimate varicella seasonality, and we used clustering and matrix correlation methods to assess its correlation with climate. Furthermore, we developed a mathematical model to examine whether including the effect of climate on varicella transmission could reproduce the observed spatiotemporal patterns.

Results:
Varicella seasonality was markedly bimodal, with latitudinal changes in the peaks' timing and amplitude. This spatial gradient strongly correlated with specific humidity (Mantel statistic = 0.412, P = .001) but not temperature (Mantel statistic = 0.077, P = .225). The mathematical model reproduced the observed patterns not only in Colombia but also México, and it predicted a latitudinal gradient in Central America.

Conclusions:
These results demonstrate large variability in varicella seasonality across Colombia and suggest that spatiotemporal humidity fluctuations can explain the calendar of varicella epidemics in Colombia, México, and potentially in Central America.