Publikationsdatenbank

Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Kreye, Jakob

Reincke, Momsen

Edelburg, Stefan

Jeworowski, Lara M.

Kornau, Hans-Christian

Trimpert, Jakob (WE 5)

Hombach, Peter

Halbe, Sophia

Nölle, Volker

Meyer, Martin

Kattenbach, Stefanie

Sánchez-Sendin, Elisa

Schmidt, Marie L.

Schwarz, Tatjana

Rose, Ruben

Krumbholz, Andi

Merz, Sophie

Adler, Julia Maria (WE 5)

Eschke, Kathrin

Abdelgawad, Azza

Schmitz, Dietmar

Sander, Leif Erik

Janssen, Uwe

Corman, Victor M.

Prüss, Harald

Quelle

iScience

Bandzählung: 26

Heftzählung: 4

Seiten: Artikel 106323

ISSN: 2589-0042

Sprache

Englisch

Verweise

URL (Volltext): https://pubmed.ncbi.nlm.nih.gov/36925720/

DOI: 10.1016/j.isci.2023.106323

Pubmed: 36925720

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The recurrent emerging of novel viral variants of concern (VOCs) with evasion of preexisting antibody immunity upholds severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case numbers and maintains a persistent demand for updated therapies. We selected the patient-derived antibody CV38-142 based on its potency and breadth against the VOCs Alpha, Beta, Gamma, and Delta for preclinical development into a therapeutic. CV38-142 showed in vivo efficacy in a Syrian hamster VOC infection model after post-exposure and therapeutic application and revealed a favorable safety profile in a human protein library screen and tissue cross-reactivity study. Although CV38-142 targets the same viral surface as sotrovimab, which maintains activity against Omicron, CV38-142 did not neutralize the Omicron lineages BA.1 and BA.2. These results highlight the contingencies of developing antibody therapeutics in the context of antigenic drift and reinforce the need to develop broadly neutralizing variant-proof antibodies against SARS-CoV-2.