Publikationsdatenbank

Clinical Evidence for the use of Octenidine Dihydrochloride to Prevent Healthcare-associated Infections and Decrease Staphylococcus aureus Carriage or Transmission:
a Review (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Köck, Robin

Denkel, Luisa

Feßler, Andrea T. (WE 7)

Eicker, Rudolf

Mellmann, Alexander

Schwarz, Stefan (WE 7)

Geffers, Christine

Hübner, Nils-Olaf

Leistner, Rasmus

Quelle

Pathogens

Bandzählung: 12

Heftzählung: 4

Seiten: 1 – 14

ISSN: 2076-0817

Sprache

Englisch

Verweise

URL (Volltext): https://pubmed.ncbi.nlm.nih.gov/37111498/

DOI: 10.3390/pathogens12040612

Pubmed: 37111498

Kontakt

Institut für Mikrobiologie und Tierseuchen

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51843 / 66949
mikrobiologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Background: The antiseptic agent octenidine dihydrochloride (OCT) is used for skin preparation, for Staphylococcus aureus decolonization, and within bundles for the prevention of catheter-related or surgical site infections (SSIs). Here, we review the evidence for the effects of OCT from clinical studies.

Methods: Review of studies published in the Medline, Scopus, and Cochrane databases until August 2022, performed in clinical settings and reporting on effects of OCT on S. aureus carriage/transmission, SSI prevention, and prevention of intensive care unit (ICU)-related or catheter-related bloodstream and insertion site infections.

Results: We included 31 articles. The success of S. aureus decolonization with OCT-containing therapies ranged between 6 and 87%. Single studies demonstrated that OCT application led to a reduction in S. aureus infections, acquisition, and carriage. No study compared OCT for skin preparation before surgical interventions to other antiseptics. Weak evidence for the use of OCT for pre-operative washing was found in orthopedic and cardiac surgery, if combined with other topical measures. Mostly, studies did not demonstrate that daily OCT bathing reduced ICU-/catheter-related bloodstream infections with one exception.

Conclusions: There is a need to perform studies assessing the clinical use of OCT compared with other antiseptics with respect to its effectiveness to prevent nosocomial infections.