Publikationsdatenbank

Linking the mechanics of chewing to biology of the junctional epithelium (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Yuan, X.

Liu, B.

Cuevas, P.

Brunski, J.

Aellos, F.

Petersen, J.

Koehne, T.

Bröer, S. (WE 14)

Grüber, R.

LeBlanc, A.

Zhang, X.

Xu, Q.

Helms, J. A.

Quelle

Journal of dental research : JDR ; featuring critical reviews in oral biology & medicine

Bandzählung: 102

Heftzählung: 11

Seiten: 1252 – 1260

ISSN: 0022-0345

Sprache

Englisch

Verweise

URL (Volltext): http://journals.sagepub.com/doi/10.1177/00220345231185288

DOI: 10.1177/00220345231185288

Pubmed: 37555395

Kontakt

Institut für Pharmakologie und Toxikologie

Koserstr. 20
14195 Berlin
+49 30 838 53221
pharmakologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

The capacity of a tissue to continuously alter its phenotype lies at the heart of how an animal is able to quickly adapt to changes in environmental stimuli. Within tissues, differentiated cells are rigid and play a limited role in adapting to new environments; however, differentiated cells are replenished by stem cells that are defined by their phenotypic plasticity. Here we demonstrate that a Wnt-responsive stem cell niche in the junctional epithelium is responsible for the capability of this tissue to quickly adapt to changes in the physical consistency of a diet. Mechanical input from chewing is required to both establish and maintain this niche. Since the junctional epithelium directly attaches to the tooth surface via hemidesmosomes, a soft diet requires minimal mastication, and consequently, lower distortional strains are produced in the tissue. This reduced strain state is accompanied by reduced mitotic activity in both stem cells and their progeny, leading to tissue atrophy. The atrophied junctional epithelium exhibits suboptimal barrier functions, allowing the ingression of bacteria into the underlying connective tissues, which in turn trigger inflammation and mild alveolar bone loss. These data link the mechanics of chewing to the biology of tooth-supporting tissues, revealing how a stem cell niche is responsible for the remarkable adaptability of the junctional epithelium to different diets.