Publikationsdatenbank

Presence of porcine cytomegalovirus, a porcine roseolovirus, in wild boars in Italy and Germany (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Hansen, Sabrina (WE 5)

Menandro, Maria Luisa

Franzo, Giovanni

Krabben, Ludwig (WE 5)

Marino, Stephen F.

Kaufer, Benedikt (WE 5)

Denner, Joachim (WE 5)

Quelle

Archives of virology : official journal of the Virology Division of the International Union of Microbiological Societies

Bandzählung: 168

Heftzählung: 2

Seiten: Article number: 55

ISSN: 0304-8608

Sprache

Englisch

Verweise

URL (Volltext): https://link.springer.com/article/10.1007/s00705-022-05690-6

DOI: 10.1007/s00705-022-05690-6

Pubmed: 36609605

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Porcine cytomegalovirus (PCMV), a porcine roseolovirus (PRV) that is closely related to human herpesviruses 6 and 7, is commonly found in commercial pigs. PCMV/PRV is important in xenotransplantation, because in preclinical trials in which pig organs were transplanted into non-human primates, transmission of PCMV/PRV was shown to be associated with significantly reduced survival of the xenotransplants. PCMV/PRV was also transmitted in the first transplantation of a pig heart into a human patient worldwide and apparently contributed to the death of the patient. The prevalence of PCMV/PRV in wild boars is largely unknown. In this study, we screened wild boars from several areas of northern Italy and Germany to test for the presence of PCMV/PRV using PCR-based and Western blot assays. By Western blot analysis, 54% and 82% of Italian and German wild boars, respectively, were found to be PCMV/PRV positive, while 36% and 60%, respectively, tested positive by real-time polymerase chain reaction (PCR). These data indicate that the virus is common in German and Italian wild boars and that the Western blot assay detected a PCMV/PRV infection more often than did real-time PCR. The data also indicate that pigs raised for xenotransplantation should be protected from contact with materials from wild boars and commercial pigs.