Publication Database

Mucin-inspired single-chain polymer (MIP) fibers as potent SARS-CoV-2 inhibitors (2023)

Art

Zeitschriftenartikel / wissenschaftlicher Beitrag

Autoren

Bej, Raju

Nie, Chuanxiong

Ludwig, Kai

Ahmadi, Vahid

Trimpert, Jakob (WE 5)

Adler, Julia M. (WE 5)

Povolotsky, Tatyana L.

Achazi, Katharina

Kagelmacher, Marten

Vidal, Ricardo Martin (WE 5)

Dernedde, Jens

Kaufer, Benedikt B. (WE 5)

Haag, Rainer

Quelle

Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker. - International edition

Bandzählung: 62

Heftzählung: 29

Seiten: Artikel e202304010

ISSN: 1433-7851

Sprache

Englisch

Verweise

URL (Volltext): https://onlinelibrary.wiley.com/doi/10.1002/anie.202304010

DOI: 10.1002/anie.202304010

Pubmed: 37130003

Kontakt

Institut für Virologie

Robert-von-Ostertag-Str. 7-13
14163 Berlin
+49 30 838 51833
virologie@vetmed.fu-berlin.de

Abstract / Zusammenfassung

Mucins are the key component of the defensive mucus barrier. They are extended fibers of very high molecular weight with diverse biological functions depending strongly on their specific structural parameters. Here, we present a mucin-inspired nanostructure, produced via a synthetic methodology to prepare methacrylate-based dendronized polysulfates (MIP-1) on a multi gram-scale with high molecular weight (MW=450 kDa) and thiol end-functionalized mucin-inspired polymer (MIP) via RAFT polymerization. Cryo-electron tomography (Cryo-ET) analysis of MIP-1 confirmed a mucin-mimetic wormlike single-chain fiber structure (length=144±59 nm) in aqueous solution. This biocompatible fiber showed promising activity against SARS-CoV-2 and its mutant strain, with a remarkable low half maximal (IC50 ) inhibitory concentration (IC50 =10.0 nM). Additionally, we investigate the impact of fiber length on SARS-CoV-2 inhibition by testing other functional polymers (MIPs) of varying fiber lengths.